Using rTMS to Explore Neural Mechanisms of Stress-Induced Opioid Use
Status:
Not yet recruiting
Trial end date:
2025-06-01
Target enrollment:
Participant gender:
Summary
This study will use a stress (vs. placebo) exposure model, paired with single-session sham
vs. active rTMS at two distinct cortical locations (dlPFC vs. mPFC in parallel groups) to
assess whether rTMS neuromodulation at these alternative loci differentially influence
stress-reactivity and opioid reinforcement in non-treatment seeking participants with OUD.
Stress-reactivity will be measured using cognitive, affective, behavioral and biological
phenotypes.