Utility of Sodium Lactate Infusion During Septic Shock

• Status: Recruiting
• Trial end date: 2021-11-01
• Target enrollment: 0
• Participant gender: All

Summary

ULIS-1 is an open-label pilot study concerning utility of molar sodium lactate in fluid balance in septic shock patients

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Lille

Criteria

Inclusion Criteria:

• Presence of septic shock

• requiring vascular filling within 12 hours after introduction of Noradrenaline. Septic shock is defined as sepsis with persistent hypotension requiring the administration of vasopressors to maintain RTE > 65mmHg.

• social insurance

Exclusion Criteria:

• pregnancy

• cardiac arrest

• more than 50ml/kg of fluid loading

• chronic renal failure with chronic hemodialysis or the investigators estimate a need for renal replacement therapy in the following 24hrs

• child C or acute liver failure with PT<40% (unless AVK)

• plasmatic sodium <120 or >145mmol/l

• metabolic alkalosis with pH>7.45