V2 Receptor Effects on Fluid Regulation and Performance

• Status: Completed
• Trial end date: 2012-10-01
• Target enrollment: 0
• Participant gender: All

Summary

This primary aim of this study was to critically assess whether or not sweat water content and sodium concentration were acutely regulated by dynamic changes in antidiuretic hormone (arginine vasopressin or AVP) acting on the Vasopressin 2 receptor (V2R) during exercise. Secondary aims were to evaluate running performance and core temperature to further characterize the role of AVP in the coordinated balance of fluid and temperature homeostasis during exercise. The primary hypothesis was that activation of the V2R in sweat glands would result in water reabsorption and fluid conservation during endurance exercise.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Oakland University
• Collaborator: Georgetown University
• Treatments: Arginine Vasopressin; Tolvaptan; Vasopressins

Criteria

Inclusion Criteria:

• Healthy (no acute or chronic medical conditions or regular prescription medication use), habitual (>50km/week)

• Distance runners between the ages of 18-60 years.

Exclusion Criteria:

• Individuals with chronic medical problems which require regular prescription medication

• Runners with pre-existing kidney problems

• Unable to sense thirst

• Difficulty swallowing

• Gastrointestinal disorders

• History of fainting associated with blood draw.