VNP40101M and Cytarabine in Treating Patients With Hematologic Malignancies

• Status: Completed
• Trial end date: 2008-01-01
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Drugs used in chemotherapy, such as VNP40101M and cytarabine, use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells.

PURPOSE: Phase I trial to study the effectiveness of combining VNP40101M with cytarabine in treating patients who have hematologic malignancies, including myelodysplastic syndrome or relapsed, refractory, or untreated leukemia.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Vion Pharmaceuticals
• Collaborator: National Cancer Institute (NCI)
• Treatments: Cytarabine

Criteria

DISEASE CHARACTERISTICS:

• Diagnosis of leukemia or myelodysplastic syndromes (MDS) meeting criteria for 1 of the following:

• Relapsed or refractory leukemia for which there is no standard therapy anticipated to result in a durable remission

• Acute myeloid leukemia

• Acute lymphocytic leukemia

• Chronic myelogenous leukemia

• In blast crisis

• Untreated leukemia and standard therapy is refused

• Any of the following poor-risk MDS:

• Refractory anemia with excess blasts (RAEB)

• RAEB in transformation

• Chronic myelomonocytic leukemia

• CNS leukemia allowed

PATIENT CHARACTERISTICS:

Age

• 18 and over

Performance status

• ECOG 0-2

Life expectancy

• Not specified

Hematopoietic

• Not specified

Hepatic

• Bilirubin no greater than 1.5 times upper limit of normal (ULN)

• ALT or AST no greater than 3 times ULN

• Chronic hepatitis allowed

Renal

• Creatinine no greater than 2.0 mg/dL

Cardiovascular

• No active heart disease

• No myocardial infarction within the past 3 months

• No symptomatic coronary artery disease

• No arrhythmias uncontrolled by medication

• No uncontrolled congestive heart failure

Other

• Not pregnant or nursing

• Negative pregnancy test

• Fertile patients must use effective contraception

• No persistent chronic toxic effects from prior chemotherapy greater than grade 1

• No uncontrolled active infection

• Infections under control and under active treatment with antibiotics allowed

PRIOR CONCURRENT THERAPY:

Biologic therapy

• Not specified

Chemotherapy

• At least 48 hours since prior hydroxyurea

Endocrine therapy

• Not specified

Radiotherapy

• Not specified

Surgery

• Not specified

Other

• At least 2 weeks since prior myelosuppressive cytotoxic agents (in the absence of rapidly progressing disease)

• No other concurrent standard or investigational treatment for leukemia

• No concurrent disulfiram