Vaginal Administration of Metformin in PCOS Patients.

• Status: Unknown status
• Trial end date: 2014-02-01
• Target enrollment: 0
• Participant gender: Female

Summary

Polycystic ovary syndrome is a common cause of irregular periods, poor ovulation and delay in achieving pregnancy. Certain drugs may help improve ovarian activity in such women as metformin. Oral administration of metformin is accompanied by undesirable side effects. The vagina proved to be a good alternative to the oral route for other drugs. Using metformin through the vagina and avoidance of such side effects, while maintaining its effectiveness, would help women to better tolerate this drug.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assiut University
• Treatments: Metformin

Criteria

Inclusion Criteria:

• women with PCOS according to the Rotterdam criteria

• age 20-35 years

• not to have received any induction of ovulation in the preceding 3 months before enrollment

Exclusion Criteria:

• contraindications to metformin

• prior surgical management of PCOS