Vaginal Estradiol Pretreatment in Labour Induction With Misoprostol

• Status: Completed
• Trial end date: 2016-02-01
• Target enrollment: 0
• Participant gender: Female

Summary

To assess the effect of vaginal estradiol pretreatment before vaginal misoprostol on labor induction.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Ain Shams University
• Treatments: Estradiol; Estradiol 17 beta-cypionate; Estradiol 3-benzoate; Estradiol valerate; Ethinyl Estradiol; Misoprostol; Polyestradiol phosphate

Criteria

Inclusion criteria:

• Maternal age ≥ 18 years old.

• Gestational age ≥ 37 wks to 41 wks.

• BMI between 20 kg/m2 and 35kg/m2.

• Vertex presentation.

• Singleton pregnancy.

Exclusion criteria:

• Multiple pregnancy.

• Non vertex presentation.

• Absolute or relative contraindication to vaginal delivery e.g. (Placenta previa, fibroid uterus, uterine anomalies, previous uterine surgery).

• PROM.

• IUFD.

• Fetal distress.