Vaginal Estrogen for the Prevention of Recurrent Urinary Tract Infection in Postmenopausal Women
Status:
Completed
Trial end date:
2017-12-01
Target enrollment:
Participant gender:
Summary
The investigators would like to know if the use of vaginally applied estrogen can prevent the
problem of repeated urinary tract infections (UTI) in women who have gone through menopause.
The investigators will use two forms of vaginal estrogen that are available by prescription
(a ring and a cream) and compare their efficacy to that of a placebo (without any active
ingredient). The investigators are going to look at if the vaginal estrogen can prevent UTIs
altogether and also the number of UTIs each group experiences over a 6 month period. After 6
months, all subjects will receive vaginal estrogen and the women on the non-active treatment
will be able to choose whether they would like to use either the estrogen ring or cream. The
investigators will then be able to compare the number of UTIs on and off active vaginal
estrogen treatment within those subjects who started on the placebo. The investigators are
also going to look at quality of life before and during treatment using questionnaires and
whether subjects stop using the treatments or do not use them as directed (compliance).
Phase:
Phase 4
Details
Lead Sponsor:
University of California, San Diego
Collaborators:
American Urogynecologic Society New York University Langone Medical Center NYU Langone Health