Vaginal Prednisone Administration for Prevention of Adrenal Crisis
Status:
Completed
Trial end date:
2017-06-01
Target enrollment:
Participant gender:
Summary
Patients with chronic adrenal insufficiency need to adapt their glucocorticoid replacement
dose in conditions of physical or psychological stress to prevent life threatening adrenal
crisis. In cases of more severe impairment or unsecure gastrointestinal absorption (e.g.
gastroenteritis, severe infectious disease), rapid and highly dosed administration of
glucocorticoids is crucial. The study is conducted to offer female patients the possibility
to perform efficient prednisone self-administration in emergency situations in a way of
administration, which is easy to perform and accepted by the patients. Therefore,
pharmacokinetics and safety of vaginal prednisone administration will be studied and compared
to rectal administration.