Vaginal Progesterone for Prevention of Preterm Labor in Asymptomatic Twin Pregnancies With Sonographic Short Cervix

• Status: Completed
• Trial end date: 2014-11-01
• Target enrollment: 0
• Participant gender: Female

Summary

To evaluate the value of vaginal progesterone therapy for reduction of preterm labor in asymptomatic twin pregnancies who have sonographic short cervix

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mohamed Sayed Abdelhafez
• Treatments: Progesterone

Criteria

Inclusion Criteria:

• Women pregnant in dichorionic twins.

• Transvaginal sonographic cervical length is 20-25 mm at 20-24 weeks gestational age.

• No symptoms, signs or other risk factors for preterm labor.

Exclusion Criteria:

• Age < 20 years or > 35 years.

• Known allergy or contraindication (relative or absolute) to progesterone therapy.

• Pregnancy by in vitro fertilization (IVF) / intracytoplasmic sperm injection (ICSI).

• Monochorionic twins.

• Known major fetal structural or chromosomal abnormality.

• Intrauterine death of one fetus or death of both fetuses.

• Fetal reduction in current pregnancy.

• Cervical cerclage in current pregnancy.

• Medical conditions that may lead to preterm delivery.

• Rupture of membranes.

• Vaginal bleeding.