Vaginal Progesterone for the Prevention of Preterm Birth in Women With Arrested Preterm Labor
Status:
Terminated
Trial end date:
2018-05-07
Target enrollment:
Participant gender:
Summary
Preterm birth, defined as birth before 37 weeks' gestation, is a leading cause of infant
death and disease. Progesterone is the single most effective intervention in the prevention
of preterm birth. However, current use of this therapy is limited to certain high-risk groups
including women with a history of preterm birth and women with a short cervix. This study
seeks to evaluate the efficacy of this preventive therapy in another high-risk group: women
with arrested preterm labor. The investigators hypothesize that administration of vaginal
progesterone in women who present with preterm labor but remain undelivered 12 hours after
cessation of short-term therapy to inhibit contractions will result in lower rates of preterm
birth before 37 weeks' than will administration of placebo.