Validate a Pharmacodynamic Model of Oxytocin for Peripheral Analgesic Effects
Status:
Not yet recruiting
Trial end date:
2024-01-01
Target enrollment:
Participant gender:
Summary
The goal of this study is to validate the pharmacodynamic model for pain relief from oxytocin
at a peripheral site by intravenous infusion targeted at different levels of the drug.
In this study healthy volunteers and people with knee arthritis so severe that they may need
joint replacement are recruited for a one day study. Each study participant will have an
intravenous(IV) catheter placed. After placement of the IV catheter oxytocin will be given by
IV infusion in varying amounts. The study team will perform some tests to evaluate how
oxytocin changes perceptions on the skin. The study team will study a painful perception by
placing a probe on the skin and heating it to 113 degrees Fahrenheit for 5 minutes. Each
study participant will score any pain that is experienced on a 0 to 10 scale.