Validation of Aspiration Markers in Intubated Patients

• Status: Recruiting
• Trial end date: 2022-06-30
• Target enrollment: 0
• Participant gender: All

Summary

The goal of this interventional study is to test Quinine as marker of aspiration (endotracheal tube [ETT] cuff leakage) in mechanically ventilated, critically ill patients.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Massachusetts General Hospital

Criteria

Inclusion Criteria:

• Age ≥ 18 years

• Admission to Surgical ICUs (MGH Ellison 4 or Blake 12)

• Patients expected to be intubated for at least 48 hours or longer from the time of enrollment.

Exclusion Criteria:

• High PEEP requirement at enrollment (PEEP higher than 8 cmH2O)

• Diagnosis of ARDS (any severity)

• Status asthmatics

• Current or past participation in another interventional trial conflicting with the present study

• Pregnant women

• Prisoner status

• Patients who had partial or total gastrectomy.