Validation of International Warfarin Pharmacogenetics Consortium (IWPC) Algorithm in Elderly Patients With Comorbidity

• Status: Unknown status
• Trial end date: 2018-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to validate the International Warfarin Pharmacogenetics Consortium (IWPC) algorithm in a prospective cohort of elderly people (65 years or older) with heart valves and/or nonvalvular atrial fibrillation (AF) and at least one comorbid condition, and to assess the algorithm's prognostic relevance.

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Second University of Naples; University of Campania "Luigi Vanvitelli"
• Collaborators: Federico II University; University of Salerno
• Treatments: Warfarin

Criteria

Inclusion Criteria:

• Age ≥ 65 years

• Patients who initiate warfarin because of non valvular atrial fibrillation or heart valve replacement

• At least one comorbid condition

• At least two other drugs regularly assumed over and above warfarin

Exclusion Criteria:

• Presence of systemic coagulopathies

• Presence of malignancies needing chemotherapy

• Inability or refusal to give informed consent