Validity Study of Glutamine to Improve Cardiac Function in Cardiac Surgery
Status:
Completed
Trial end date:
2014-03-01
Target enrollment:
Participant gender:
Summary
In view of the lack of large-scale clinical study and potent evidence-based medicine, the
investigators designed a randomized, double-blind, placebo-controlled study to ascertain
whether preoperative intravenous administration with glutamine can improve the postoperative
cardiac function and prognosis of adult patients undergoing cardiac surgery. The
investigators want to detect the levels of myocardial protein O-GlcNAc modification and HSP70
expression, changes in sensitive indicators of myocardial injury, systemic inflammatory
reaction and oxidative stress levels, and to examine the correlation between these changes
and Clinical manifestations. The ultimate goal of the study is to explore a new way for
clinical myocardial protection.