Vancomycin Dosage Strategy Based on a Trough Concentration Model

• Status: Recruiting
• Trial end date: 2021-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Study design:

Allocation: Randomized Endpoint classification: Efficacy study Masking: Open label Primary purpose: Treatment Primary endpoint: Incidence of reaching the target serum trough concentration Secondary endpoint: Clinical efficiency, Antibiotic use, acute kidney injury.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Peking University Third Hospital
• Treatments: Vancomycin

Criteria

Inclusion Criteria:

• Patients with doubted or diagnosed Methicillin-resistant Staphylococcus aureus severe pneumonia, and need vancomycin treatment.

• Sixty years and older.

Exclusion Criteria:

• younger than 60 years old

• Accepted blood purification therapy

• Pregnancy

• Positive HIV antibody titre

• Had known or suspected tuberculosis or other infections caused by fungi at baseline.