Vancomycin Tissue Concentrations by Bier Block or Intravenous Administration

• Status: Enrolling by invitation
• Trial end date: 2022-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether or not giving a lower dose of antibiotics (Vancomycin) in the area where it is needed (upper extremity) is more effective at preventing infection than the current standard dose which is given intravenously (IV).

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mayo Clinic
• Treatments: Vancomycin

Criteria

Inclusion Criteria:

• Patients undergoing upper extremity reconstruction by a single surgeon.

• Surgical cases will include:

• Trapeziectomy/suspensionplasty.

• PIPJ/MPJ arthroplasty.

• Proximal row carpectomy.

• Distal ulnar resection.

• Distal radius fracture fixation.

Exclusion Criteria:

• Inability to adequately cannulate a superficial vein in the upper extremity within 5 minutes of tourniquet inflation.

• Evidence of subcutaneous extravasation in Bier block group.

• History of renal dysfunction.

• Vancomycin allergy.

• ASA>/= 3.

• History of lung cancer.

• Known HIV infection.

• History of organ transplantation.