Varenicline Smoking Cessation Treatment for Methadone Maintenance Patients

• Status: Completed
• Trial end date: 2015-07-01
• Target enrollment: 0
• Participant gender: All

Summary

This randomized trial will evaluate whether varenicline directly observed therapy provided at a methadone clinic is more efficacious than self-administered varenicline for promoting smoking cessation and enhancing adherence.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Albert Einstein College of Medicine
• Collaborator: National Institute on Drug Abuse (NIDA)
• Treatments: Varenicline

Criteria

Inclusion Criteria:

• Age 18 years or older

• English speaking

• Smoked at least 100 cigarettes/lifetime

• Smoke 5 or more cigarettes per day

• Interested in quitting smoking (preparation or contemplation stage of change)

• Enrolled in Einstein/Montefiore methadone program for 12 weeks or more

• Receiving methadone in clinic three, four, five or six times per week

• No more than 2 methadone clinic misses in prior 14 days

• Agree to use contraception for the duration of the trial (among women with reproductive potential)

• Willing to participate in all study components

• Able to provide informed consent

Exclusion Criteria:

• Serious or unstable HIV/AIDS, liver, cardiovascular, or pulmonary disease

• Psychiatric instability

• Women who are pregnant, breastfeeding, or contemplating pregnancy

• Creatinine clearance <30 mL/min