Varenicline and Motivational Advice for Smokers With Substance Use Disorders

• Status: Completed
• Trial end date: 2014-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate the effects of 12 weeks of varenicline as compared to nicotine replacement therapy for smoking cessation among outpatients in treatment for substance use disorders. The intervention also incorporates counseling (Brief Advice), (adapted for sobriety settings), skills training and medication management.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Brown University
• Collaborator: National Institute on Drug Abuse (NIDA)
• Treatments: Nicotine; Varenicline

Criteria

Inclusion Criteria:

• Diagnosis of substance abuse or dependence by DSM-IV criteria

• Currently smoking at least 10 cigarettes per day for the past 6 months

Exclusion Criteria:

• Active psychosis or marked organic impairment according to medical records, or evidence of hallucinations or delusions

• Current use of any nicotine replacement, or other smoking cessation treatment

• Medical contraindications for NRT (including pregnancy, nursing, women not using birth control during heterosexual sex, history of unstable angina, history of severe congestive heart failure, uncontrolled hypertension, lung cancer, supplemental oxygen, allergy to adhesive, severe skin disease that requires treatment)

• Medical contraindications for VAR (including pregnancy, nursing, severe renal impairment by laboratory test, history of intolerance of varenicline, history of serious suicidal ideation or attempts in the past 5 years)