Variability in Adrenergic Response

• Status: Completed
• Trial end date: 2011-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The goal of this project is to determine the genetic factors contributing to interindividual differences in response to physiological and pharmacological vasoconstrictors and vasodilators.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Vanderbilt University; Vanderbilt University Medical Center
• Collaborators: National Center for Research Resources (NCRR); National Heart, Lung, and Blood Institute (NHLBI)
• Treatments: Adrenergic Agents; Nitroglycerin; Oxymetazoline; Phenylephrine

Criteria

Inclusion Criteria:

• Age between 18 and 40 years, inclusive.

• Subject must be willing to give written informed consent and be able to adhere to diet and study schedules.

• Subjects must be free of any clinically significant disease that requires a physician's care and/or would interfere with the study evaluations.

• Subjects must have a normal or clinically acceptable physical examination and ECG.

• Clinical laboratory tests (CBC, blood chemistries, and urinalysis) must be within normal limits or clinically acceptable to the investigator.

Exclusion Criteria:

• Any subject who has taken any prescription or over-the-counter drugs, other than oral contraception if female, within two weeks prior to study drug administration.

• Subjects who are presently, or were formerly, narcotic addicts or alcoholics.

• Subjects who have a clinically significant allergy/intolerance to phenylephrine.

• Females with a positive serum/urine pregnancy test at screening.

• Females who are nursing.

• Subject using sildenafil or other phosphodiesterase inhibitors.