Vascular Dysfunction in Black Individuals: Roles of Nitric Oxide and Endothelin-1

• Status: Recruiting
• Trial end date: 2022-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The research aims of this proposal are:

• Specific Aim 1: To test whether an increase in nitric oxide signaling can increase vasodilator responses in young Black individuals.

• Specific Aim 2: To test whether a decrease in endothelin-1 signaling can increase vasodilator responses in young Black individuals.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Mississippi Medical Center
• Treatments: Bosentan; Sildenafil Citrate

Criteria

Inclusion Criteria:

• Self-identification of their race and the race of their biological parents as being only Black (i.e., African American) or only White (i.e., Caucasian American)

• Born and raised in the United States

Exclusion Criteria:

• Mixed races

• Any chronic or ongoing disease

• Prescribed pharmacological treatment

• Smoking or tobacco use

• Obesity (body mass index > 30 kg / m2)