Vascular Effects of Hesperidin in Metabolic Syndrome

• Status: Unknown status
• Trial end date: 2010-12-01
• Target enrollment: 0
• Participant gender: All

Summary

It has been suggested that cardiovascular risk factors either independently or in cluster (metabolic syndrome) increase the risk of both type 2 diabetes (DM2) and cardiovascular diseases (CVD). Consumption of citrus fruits is linked to reduced cardiovascular morbidity and mortality. Hesperidin is a flavanone abundant in citrus fruit with putative vasodilator actions in vitro. While molecular mechanisms of vascular actions of hesperidin begin to be explored, no data on in vivo vascular effect of this flavanone has been ever acquired.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Rome Tor Vergata

Criteria

Inclusion Criteria:

• Metabolic Syndrome (ATPIII criteria)

• BMI <35

• Age 20-55

Exclusion Criteria:

• History of cancer.

• History of cardiovascular diseases.

• Any other acute or chronic illness which requires administration of steroids or other drugs able to interfere with glucose or lipid metabolism.