Vasodilation Effect of Inhalational Anesthetics

• Status: Completed
• Trial end date: 2009-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Previous studies on animals suggest that inhalational anesthetics can reduce vascular tension in vitro resulting in vasodilation and decrease in blood pressure. This role for inhalational anesthetics has essential clinical implications such as the condition of sepsis or septic shock or other shock-associated states during which the blood vessel constricts strongly and leads to circulation dysfunction. The vasodilation property of these anesthetics including halothane, isoflurane, sevoflurane, desflurane and enflurane enables them to be better options than other general anesthetics in many clinical conditions needing the vasculature to be dilated. The investigators hypothesized that these inhalational anesthetics can evoke vasodilation measured with ultrasonography during general anesthesia in vivo as the in vitro studies displayed.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Nanjing Medical University
• Treatments: Anesthetics; Anesthetics, Inhalation; Desflurane; Enflurane; Halothane; Isoflurane; Sevoflurane

Criteria

Inclusion Criteria:

• Must be undergoing general anesthesia

• Age between 19-45 years

Exclusion Criteria:

• With hypertension

• Existing organic dysfunction

• Allergic to inhalant anesthetics

• Alcohol addictive or narcotic dependent patients

• A history of the use of centrally-acting drugs of any sort, chronic pain and psychiatric diseases records