Vasopressin Versus Norepinephrine for the Management of Septic Shock in Cancer Patients

• Status: Completed
• Trial end date: 2018-05-01
• Target enrollment: 0
• Participant gender: All

Summary

Although arginine vasopressin has been used as an additional drug in refractory shock in worldwide clinical practice, there are no prospective studies using it as a first choice therapy in patients with cancer and septic shock.

The aim of this study is assess if the use of arginine vasopressin would be more effective on treatment of septic shock in cancer patients than norepinephrine, decreasing the composite end point of mortality and organ failure in 28 days.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Instituto do Cancer do Estado de São Paulo
• Treatments: Arginine Vasopressin; Norepinephrine; Vasopressins

Criteria

Inclusion Criteria:

• Solid neoplasm needing ICU

• Septic Shock according standard criteria

Exclusion Criteria:

• Younger than 18 years;

• Pregnancy;

• Raynaud's phenomenon, systemic sclerosis or vasospastic diathesis;

• Severe hyponatremia (Na<130mEq/L);

• Acute mesenteric ischemia;

• Acute myocardial infarction;

• Cardiogenic shock;

• Current use of vasopressor before randomization

• Expected ICU stay less than 24 hours

• Enrolled in another study;

• Refusal to consent.