Vasopressin Versus Norepinephrine for the Management of Shock After Cardiac Surgery
Status:
Unknown status
Trial end date:
2013-05-01
Target enrollment:
Participant gender:
Summary
Vasoplegic syndrome after cardiac surgery is a common complication after cardiac surgery,
with negative impact on patient outcomes and hospital costs. Pathogenesis of vasodilatory
phenomenon after cardiac surgery remains a matter of controversy. Loss of vascular tone can
be partly explained by the depletion of neurohypophyseal arginine vasopressin stores. The
investigators hypothesized that the use of arginine vasopressin would be more effective on
treatment of shock after cardiac surgery than norepinephrine, decreasing the composite end
point of mortality and severe morbidity.