Veliparib, Radiation Therapy, and Temozolomide in Treating Younger Patients With Newly Diagnosed Diffuse Pontine Gliomas
Status:
Completed
Trial end date:
2018-03-28
Target enrollment:
Participant gender:
Summary
This phase I/II trial studies the side effects and the best dose of veliparib when given
together with radiation therapy and temozolomide and to see how well they work in treating
younger patients newly diagnosed with diffuse pontine gliomas. Veliparib may stop the growth
of tumor cells by blocking some of the enzymes needed for cell growth. Radiation therapy uses
high-energy x rays to kill tumor cells. Drugs used in chemotherapy, such as temozolomide,
work in different ways to stop the growth of tumor cells either by killing the cells or by
stopping them from dividing. Giving veliparib with radiation therapy and temozolomide may
kill more tumor cells.