Overview

Venetoclax and Lintuzumab-Ac225 in AML Patients

Status:
Recruiting
Trial end date:
2023-01-01
Target enrollment:
Participant gender:
Summary
The study is a multicenter, open label Phase I/II trial. 1. To determine the maximum tolerated dose (MTD) of lintuzumab-Ac225 added to venetoclax for patients with CD33 positive relapsed/refractory AML. (Phase 1 portion) 2. To assess the percentage of patients with CR, CRh, or Overall Response (CR + CRh), up to 6 months after the start of treatment without receiving other AML therapies. (Phase 2 portion)
Phase:
Phase 1/Phase 2
Details
Lead Sponsor:
Actinium Pharmaceuticals
Treatments:
Antibodies, Monoclonal
Lintuzumab
Spironolactone
Venetoclax