Ventilation and Pulmonary Endothelium Toxicities of E-cigarettes: A Randomized Crossover Pilot Study
Status:
Completed
Trial end date:
2018-07-24
Target enrollment:
Participant gender:
Summary
Determination of the acute pulmonary toxicities of e-cigarettes in young adults is of major
public health importance, as e-cigarette vapor contains established toxicants that as
hypothesized cause acute damage to the airways and the pulmonary microvasculature that may
promote the development of CLD, for which there remain few effective therapies.
The study therefore propose a pilot study using a randomized crossover design in ten healthy
young adults to test the acute effects of a standardized e-cigarette exposure on two
sensitive, safe, non-invasive imaging measures: (1) ventilation defects on hyperpolarized
helium-enhanced magnetic resonance imaging, and (2) pulmonary microvascular blood flow on
gadolinium-enhanced pulmonary magnetic resonance angiography.