Ventilation-drive Coupling to Evaluate The Efficacy of Inhaled Bronchodilators in Patients With COPD
Status:
Completed
Trial end date:
2015-05-01
Target enrollment:
Participant gender:
Summary
Chronic Obstructive Pulmonary Disease (COPD) is a major cause of chronic morbidity, mortality
and disability throughout the world, leading to a heavy social and economic
burden.Bronchodilators, the most commonly used drugs in COPD patients, have been shown to
reduce dyspnea, improve exercise tolerance and improve health status. However,conventional
lung function parameters such as forced vital capacity (FVC) and forced expiratory volume in
one second (FEV1) frequently fail to detect significant functional responses to
bronchodilators in patients with chronic airflow obstruction. It is necessary for clinical
and scientific reasons to develop a new tool to objectively assess the effect of different
treatments including bronchodilator on COPD. Our previous study showed that Ventilation-drive
coupling may be more sensitive and accurate to evaluate the efficacy of inhaled
bronchodilators in patients with COPD because it could better reflect the pathological and
physiological characteristics of COPD.
Based on the above conclusion, the present study were performed using the experimental
methods of placebo and self-controlled. We aimd to explore the value of ventilation-drive
coupling in evaluating the efficacy of bronchodilators on COPD and provide a reasonable basis
for the clinical application of this index.