Ventilator-Associated Pneumonia/Hospital-Acquired Pneumonia Requiring Mechanical Ventilatory Support
Status:
Completed
Trial end date:
2004-09-01
Target enrollment:
Participant gender:
Summary
The purpose of the study is to find out if high dose antibiotic (meropenem, MERREM® I.V.),
along with another drug called an aminoglycoside (a different type of antibiotic) is
effective in decreasing or reducing the rate of antibiotic resistant Pseudomonas aeruginosa,
Acinetobacter (germs that can cause pneumonia), and the rate of resistance in other difficult
to treat germs which may cause hospital-acquired pneumonia requiring mechanical ventilatory
support. The study hopes to show that by increasing the amount of meropenem administered and
increasing the duration of infusion (release of the drug into the bloodstream), levels of the
drug will stay at target levels in the bloodstream and decrease the ability of difficult to
treat germs to resist, or not be killed by, the treatment using this antibiotic (meropenem)
or other antibiotics.