Ventricular Repolarization in Patients With Premature Ovarian Insufficiency (QT-IOP)
Status:
Recruiting
Trial end date:
2024-06-12
Target enrollment:
Participant gender:
Summary
Ventricular repolarization, measured by corrected QT interval (QTc), is influenced by sex
hormones. A QTc above 460msec predisposes to the risk of "torsades-de-pointes"(TdP). The
investigators have recently shown that estradiol determines an increase in QTc elongation and
progesterone shortens it. In addition, high gonadotropin levels (FSH or LH) are associated
with QTc prolongation. Hypergonadotropic hypogonadisms (low progesterone and high
gonadotropins) are therefore hormonal situations that promote QTc prolongation. Premature
ovarian insufficiency (POI) is one of them. Its management is based on the prescription of
hormone replacement therapy (HRT). Epidemiological studies have shown that these patients
would be at increased risk of cardiovascular mortality. Our team is interested in the effect
of this pathological hormonal situation and its HRT on ventricular repolarization in order to
define whether this is a population at risk for long QTc.