Very Intense Radiotherapy-Chemotherapy Regimen in Advanced HNSCC

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Altered fractionated radiotherapy and concomitant radio-chemotherapy have been shown to be two possibilities for improving efficacy of radiotherapy in locally advanced head and neck carcinomas. In this multicentric study, we tested the hypothesis that accelerated radiotherapy could be delivered concomitantly with conventional high doses of CDDP-5FU, aiming to improve both local control and on distant metastases as compared to very accelerated radiotherapy.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Gustave Roussy, Cancer Campus, Grand Paris

Criteria

Inclusion Criteria:

• palpable N2b-c or N3 (UICC 1997) squamous cell carcinoma of the head and neck (oropharynx, oral cavity, hypopharynx or larynx)

• primary tumor and / or nodal extension strictly inoperable due to the extension of the disease

• performance status of 0 to 2 (WHO scoring system)

• renal/liver/cardiac functions and blood counts compatible with the use of CDDP and 5-FU

• signed inform consent

Exclusion Criteria:

• distant metastasis

• previous history of cancer

• previous radiotherapy or chemotherapy