Vincristine, DOXIL (Doxorubicin HCl Liposome Injection) and Dexamethasone vs. Vincristine, Doxorubicin, and Dexamethasone in Patients With Newly Diagnosed Multiple Myeloma

• Status: Completed
• Trial end date: 2004-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine how well newly diagnosed multiple myeloma patients respond to an experimental regimen of Vincristine, DOXIL (doxorubicin HCl liposome injection) and Dexamethasone (VDD) versus the standard treatment of Vincristine, Doxorubicin and Dexamethasone (VAD).

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
• Collaborator: Tibotec Therapeutics, a Division of Ortho Biotech Products, L.P., USA
• Treatments: BB 1101; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate; Doxorubicin; Liposomal doxorubicin; Vincristine

Criteria

Inclusion Criteria:

• Untreated multiple myeloma requiring treatment

• Total cumulative dose of prior doxorubicin can not exceed 240 mg/m2

• Must have measurable disease

• Left Ventricular Ejection Fraction (LVEF) >= 50 % determined by Multiple Gated Acquisition Scan (MUGA)

• Karnofsky performance status of >= 60%

• Adequate bone marrow, liver and renal function

• Disease-free from prior malignancies >= 5 years with the exception of basal cell or squamous cell carcinoma of the skin or carcinoma in situ of the cervix

• Female participants (if of child bearing potential and sexually active) and male participants (if sexually active with a partner of child-bearing potential) must use medically acceptable methods of birth control.

Exclusion Criteria:

• Life expectancy of >= 3 months

• Pregnant or breast feeding

• History of cardiac disease, with New York Heart Association Class II or greater, with congestive heart failure

• or unstable angina, uncontrolled hypertension or cardiac arrythmias or myocardial infarction within the last 6 months

• Uncontrolled diabetes mellitus or systemic infection

• Nonsecretory myeloma, Monoclonal Gammopathy of Unknown Significance (MGUS) or smoldering myeloma

• Confusion, disorientation, or history of psychiatric illness which may impair patient's ability to give informed consent

• Prior chemotherapy to treat Multiple Myeloma

• Prior radiotherapy to an area greater than 1/3 of the skeleton

• Prior local radiotherapy within 1 week of treatment

• Any investigational agent within 30 days of the first dose of treatment

• Prior single agent dexamethasone (or another corticosteroid) to treat Multiple Myeloma.