Virtual Histology Findings and Effects of Varying Doses of Atorvastatin Treatment
Status:
Completed
Trial end date:
2010-06-01
Target enrollment:
Participant gender:
Summary
While statin treatment may induce plaque regression, the effect of statin on plaque
composition with varying doses is unknown. This study assessed such effects by volumetric
virtual histology intravascular ultrasound (VH-IVUS).
In this prospective, randomized, double-blinded pilot study, statin-naïve patients with
stable angina requiring percutaneous coronary intervention (PCI) were randomized to receive 6
months of either atorvastatin 10mg or 40 mg daily. VH-IVUS was performed in all non-PCI
lesions at baseline and 6 months; all analyses were performed by core laboratory.