Overview
Vitamin A and Response to Endotoxin
Status:
Unknown status
Unknown status
Trial end date:
2014-06-01
2014-06-01
Target enrollment:
0
0
Participant gender:
Male
Male
Summary
Vitamin A given as treatment and pre-treatment has reduced the severity of symptoms after infusion with endotoxin in several animal models. We intend to examine the effect of vitamin A as pre-treatment on the response to endotoxin in humans. We furthermore wish to examine the long-term effects of vitamin A on the response to endotoxin. We hypothesise that vitamin A decreases endotoxin levels and TNF-alfa responses.Phase:
N/AAccepts Healthy Volunteers?
Accepts Healthy VolunteersDetails
Lead Sponsor:
Bandim Health ProjectCollaborators:
Institute for Human Nutrition, Royal Veterinary School, Copenhagen, Denmark
Uppsala University HospitalTreatments:
Retinol palmitate
Vitamin A
Vitamins
Criteria
Inclusion Criteria: Healthy, male, between 18 and 35 years of age, non-smoker, no medicine,no infections in preceding 14 days
Exclusion Criteria: