Overview

Vitamin A and Very Low Birthweight Babies (VitAL)

Status:
Completed

Trial end date:
2009-12-01

Target enrollment:
0

Participant gender:
All

Summary

Vitamin A is important for the development of healthy eyes and lungs. Very low birth weight premature babies have low body stores of vitamin A and are prone to diseases of the eye and lungs. Previous work has shown that intramuscular (IM) vitamin A reduces the number of babies who require prolonged oxygen therapy, and may also reduce the number of babies affected by retinopathy of prematurity (ROP)). There is also some evidence that the conjunctiva shows signs of deficiency of vitamin A in premature infants, particularly those who develop ROP. Our own work here in Glasgow suggests that, compared to babies born at full term, premature babies' eyes are less sensitive to light and we believe that this may reflect shortage of vitamin A in the eye. This study will examine the effects upon the eye of giving extra intramuscular vitamin A to very low birth weight, premature infants. We will also measure blood levels of vitamin A and calculate liver stores of this nutrient.

Phase:

Phase 4

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Glasgow Royal Infirmary

Collaborator:

Chief Scientist Office of the Scottish Government

Treatments:

Retinol palmitate
Vitamin A
Vitamins

Criteria

Inclusion Criteria:

- Infants born at < 32 completed weeks gestation and/or weighing < 1501 grams birth
weight who have been admitted to either Princess Royal Maternity or Queen Mother's
Hospital within the first 24 hours of life.

Exclusion Criteria:

- Congenital ocular abnormality