Vitamin B12 Acceptance and Biomarker Response Study

• Status: Completed
• Trial end date: 2015-12-01
• Target enrollment: 0
• Participant gender: All

Summary

In this study, biomarker response after supplementation with oral and intramuscular vitamin B12 will be compared in a randomized clinical trial. Electronic compliance monitoring will be used to control for non compliance as a possible confounder in oral treatment. Additionally subjective acceptance in terms of presumed preferences will be compared with oral vs. intramuscular supplementation of vitamin B12 in the view of the patient.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Basel, Switzerland
• Collaborators: Aarelab AG; University of Basel
• Treatments: Hydroxocobalamin; Vitamin B 12; Vitamin B Complex; Vitamins

Criteria

Inclusion Criteria:

• General practitioner's prescription for Vitamin B12 deficiency testing

• Age> 18 years

• Ability to give written informed consent

• Vitamin B12 serum concentrations < 200pmol/l

• indication for vitamin B12 supplementation according to the General practitioners estimation

Exclusion Criteria:

• Patients with incorrect intake of vitamin preparations containing vitamin B12

• Patients with previously diagnosed dementia

• Patients with known hereditary transcobalamin transportation defects

• lack of written and/or oral understanding in German, French, Italian or English languages