Vitamin B12 and Folate Administration on Homocysteine Concentrations After Nitrous Oxide Anesthesia

• Status: Completed
• Trial end date: 2010-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The goal of this study is to find out if giving intravenous B-vitamins before general anesthesia with nitrous oxide prevents the increase in homocysteine, a metabolite that has been linked to cardiovascular complications.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Washington University School of Medicine
• Collaborator: Foundation for Anesthesia Education and Research
• Treatments: Anesthetics; Folic Acid; Hydroxocobalamin; Nitrous Oxide; Vitamin B 12; Vitamin B Complex; Vitamins

Criteria

Inclusion Criteria:

• Adult patients scheduled for elective surgery with expected duration > 2 hours

• Healthy patients undergoing moderate surgery where the use of N2O is unproblematic

Exclusion Criteria:

• Contraindication against N2O (pneumothorax, mechanical bowel obstruction, middle ear occlusion, laparoscopic surgery, raised intracranial pressure)

• Patients requiring supplemental oxygen

• Urgent or emergent surgery

• Patients with vitamin B12 or folate deficiency or megaloblastic anemia

• Patients with seizure disorder (epilepsy)

• Allergy or hypersensitivity against IV cobalamin or folate

• Patients with Leber's disease (hereditary optic nerve atrophy)

• Patients taking supplemental vitamin B12 or folate