Vitamin C, Thiamine and Hydrocortisone for the Treatment of Septic Shock

• Status: Completed
• Trial end date: 2021-09-20
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether the combination therapy (vitamin C,thiamine and hydrocortisone) is effective in the treatment of septic shock.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Northern Jiangsu Province People's Hospital
• Treatments: Ascorbic Acid; Hydrocortisone; Hydrocortisone 17-butyrate 21-propionate; Hydrocortisone acetate; Hydrocortisone hemisuccinate; Thiamine; Vitamins

Criteria

Inclusion Criteria:

• Age 18 years old or older

• Onset of septic shock within 12 hours

Exclusion Criteria:

• Systemic corticosteroid therapy within the last 3 months before septic shock

• High-dose steroid therapy

• Immunosuppression

• Pregnant

• Known glucose-6 phosphate dehydrogenase (G-6PD) deficiency

• Known hemachromatosis

• Known allergy to vitamin C, hydrocortisone, or thiamine

• Anticipated death from a preexisting disease within 90 days after randomization (as determined by the enrolling physician)

• Refusal of the attending staff or patient family