Vitamin D Deficiency Causes Immune Dysfunction and Enables or Perpetuates the Development of Rheumatoid Arthritis
Status:
Withdrawn
Trial end date:
2011-05-01
Target enrollment:
Participant gender:
Summary
Recent studies have demonstrated that subjects with low blood levels of vitamin D are at a
higher risk of developing autoimmune diseases such as Rheumatoid Arthritis (RA). We are
pursuing these studies to test the hypothesis that restoration of vitamin D levels
ameliorates the manifestations of RA. We will test this hypothesis by inviting patients with
RA to participate in a trial that examines the effects of oral vitamin D administration on
the clinical expression of this disease. For this purpose, the participants of this trial
will be asked to take an oral dose of 2,000 units of vitamin D daily for 6 months. We will
examine the participant's joints, assess disease activity measures, and determine his/her
blood levels of vitamin D before starting this treatment and periodically thereafter.
Phase:
Phase 2
Details
Lead Sponsor:
Indiana University
Treatments:
Cholecalciferol Ergocalciferols Vitamin D Vitamins