Vitamin D Deficiency Treatment Outcomes After Non-ST-Segment Elevation Myocardial Infarction
Status:
Unknown status
Trial end date:
2019-08-01
Target enrollment:
Participant gender:
Summary
The leading cause of death in the world is due to cardiovascular events, which originate from
coronary artery stenosis therefore it affects myocardial blood flow and finally may cause
infarction. Atherosclerosis is the most debatable hypothesis in coronary stenosis. Scientists
think body inflammation is one of the main etiologies. There are many factors affect this
inflammatory process, which Vitamin D is one of them. Vitamin D deficiency has been linked to
various inflammatory diseases. However, the mechanism by which vitamin D reduces inflammation
remains poorly understood. Vitamin D deficiency is pandemic around the world with 30-50%
prevalence in adult population and several evidences advocated its association with
immune-based disease. Additionally, there are some study suggesting patients who suffered
from myocardial infarction have lower serum vitamin D level. It has been revealed Vitamin D
deficiency has numerous major drawbacks on cardiovascular system. Its deficiency benefits
atherosclerosis progression and may cause endothelial inflammation and dysfunction in
coronary artery. There is not any evidences study vitamin D deficiency treatment on non
ST-Segment Elevation Myocardial Infarction nor there is any study demonstrating its effect on
cardiovascular health through Holick's protocol. Furthermore endothelial function, cardiac
work retrieval and inflammation after 8 weeks has not been studied with this protocol yet.
According to current data, the investigators assume by treating this vital and worldwide
deficit in our body, doctors can help decrease inflammation, decelerate the atherosclerosis
progression and enhance ventricular function after infarction.
Besides all of the recognized risk factors, vitamin D deficiency should be considered a very
important and mischievous cardiovascular alarm for the body, which should be treated and
maintained through the whole life due to lack of sufficient sunlight exposure and nutrition
intake.
In preventive medicine domain, the investigators anticipate by maintaining a high level of
this vitamin in the body, cardiovascular events decrease and its burden on society will
decline to much extend leading to a higher quality of life and health worldwide.
Phase:
Phase 2
Details
Lead Sponsor:
Isfahan University of Medical Sciences
Treatments:
Cholecalciferol Ergocalciferols Vitamin D Vitamins