Vitamin D Effect on A Disintegrin-like And Metalloprotease Thrombospondin1 Motif 13& Interleukin 6 in Leukemia
Status:
Completed
Trial end date:
2021-03-15
Target enrollment:
Participant gender:
Summary
A Disintegrin-like And Metalloprotease with Thrombospondin type 1 motif 13 (ADAMTS13)
deficiency was incriminated in poor prognosis, high probability of serious complications and
mortality in acute myeloid leukemia (AML) patients. Interleukin 6 (IL-6) produced from AML
blasts decreases Cluster of differentiation 34 positive(CD34+) cells differentiation, and
inhibits the ADAMTS13 actions. Vitamin D "as an Immune-modulator" inhibits the
pro-inflammatory cytokines including IL-6. So, supplementation of vitamin D might help down
regulation of interleukin-6 production.
Aim of the study To evaluate the potential relation between Vitamin D status, ADAMTS13 and
IL-6 in AML patients.
Objectives
1. Assess Vitamin D level in AML patients
2. Assess ADAMTS13 and IL-6 in AML patients
3. Correlate between Vitamin D level and both of ADAMTS13 and IL-6