Vitamin D, Insulin Resistance, and Cardiovascular Disease

• Status: Completed
• Trial end date: 2019-01-13
• Target enrollment: 0
• Participant gender: All

Summary

In recent years, vitamin D has been shown not only to be important for bone and calcium metabolism but also for homeostasis of critical tissues involved in vascular disease in patients with diabetes. Epidemiological studies indicated the high prevalence of vitamin D deficiency among Type 2 DM patients and suggest an increased risk of cardiovascular disease and hypertension with low vitamin D levels. The objective of this proposal is to evaluate the effects of vitamin D replacement on blood pressure control and vascular disease in vitamin D deficient hypertensive patients with diabetes

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Washington University School of Medicine
• Collaborators: American Diabetes Association; National Heart, Lung, and Blood Institute (NHLBI)
• Treatments: Calcium Carbonate; Calcium, Dietary; Cholecalciferol; Ergocalciferols; Insulin; Vitamin D; Vitamins

Criteria

Inclusion Criteria:

• Type 2 diabetes

• 25 (OH) vitamin D levels < 25 ng/ml

• Age 25 to 80 years

• Not on insulin for diabetes treatment

• HbA1c 5.5% -9.5%

• Mild/moderately increased blood pressure (systolic 120-160, diastolic 80-100) off BP medications

Exclusion Criteria:

• Pregnancy

• Patients with systolic >160 or diastolic >100 mmHg

• High urine calcium or history of recurrent kidney stones

• Cardiovascular disease

• Stage 3 or worse chronic kidney disease