Vitamin D Regulates the Expression of Glucocorticoid Receptors in Blood of Severe Asthmatic Patients

• Status: Completed
• Trial end date: 2014-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Vitamin D (VitD) deficiency is a significant public health concern in many areas around the globe which has been associated with many immune-mediated diseases, including asthma. Severe asthma has been linked with a decreased glucocorticoid receptors (GR) ratio (GR-α/ GR-β ratio), indicating steroid hyporesponsiveness. Using combined in silico and in vivo approaches, aimed to explore the immunomodulatory effect of VitD on asthmatic patients diagnosed with hypovitaminosis D.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Dubai Health Authority
• Collaborator: McGill University
• Treatments: Vitamin D

Criteria

Inclusion Criteria:

• Diagnosis of asthma

• age group between 18 and 65 years

• low level of 25-hydroxyvitamin D3 (25 D3) level less than 20ng/mL

Exclusion Criteria:

• smoker patients

• less than 18 years old

• patient on Vitamin D supplementation already