Vitamin D Regulation of Gut Specific B Cells and Antibodies Targeting Gut Bacteria in Inflammatory Bowel Disease
Status:
Recruiting
Trial end date:
2024-07-01
Target enrollment:
Participant gender:
Summary
Specific Aim 1: Characterize the effects of vitamin D treatment on expression of α4β7 on B
cells in patients with inflammatory bowel disease (IBD).
Specific Aim 2: Determine the effects of vitamin D treatment on fecal immunoglobulins,
percentage of Ig-coated gut bacteria, gut microbiome composition (global and bound by
immunoglobulins) in patients with IBD and the association of these parameters with change in
α4β7+ B cells .
Specific Aim 3: Compare BCR repertoire (BCR clonotypes, immunoglobulin heavy chain gene
(IGHV), and isotype usage) between α4β7+ and α4β7- B cells in patients with IBD and identify
α4β7+ BCR clonotypes associated with Ig-bound gut bacteria .