Vitamin D Supplementation for Bipolar Depression

• Status: Completed
• Trial end date: 2015-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to whether vitamin d supplementation in those with low levels may reduce depression symptoms in people experiencing bipolar depression.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Massachusetts, Worcester
• Treatments: Cholecalciferol; Ergocalciferols; Vitamin D; Vitamins

Criteria

Inclusion Criteria:

• Adults >18years old

• Bipolar disorder (I,II or NOS),

• MADRS Score>7 (mild),

• 25(OH)D level <30ng/ml (insufficient).

• able to take the prescribed vitamin D by mouth

Exclusion Criteria:

Systemic diseases such as:

• liver and kidney diseases,

• known parathyroid disorder,

• disorders of vitamin D metabolism,

• taking vitamin D replacement therapy,

• fat digestion disorder,

• diabetes mellitus,

• gi surgery

• If the serum calcium in the range 2.50-2.55 mmol L, inclusion required a serum PTH below 5.0 pmol L-acute psychiatric urgency:

• active suicidality,

• acute psychosis,

• active substance use<6mo or

• pregnant or nursing females