Vitamin D Supplementation for the Prevention of Cardiovascular Risk
Status:
Completed
Trial end date:
2013-12-01
Target enrollment:
Participant gender:
Summary
Hypovitaminosis D is highly prevalent in the general population, particularly in obese
individuals. Besides being associated with obesity, vitamin D deficiency seems to be involved
in the pathogenesis of insulin resistance and low-grade chronic inflammation. In addition, it
has been reported that individuals with low vitamin D levels are at increased risk for
cardiovascular diseases. A healthy diet and weight loss are cornerstones in the prevention of
cardiovascular diseases. Vitamin D supplementation could increase the beneficial effects of
these lifestyle interventions. The purpose of this study is to assess whether vitamin D
supplementation in conjunction with a hypocaloric diet improves the cardiometabolic profile
of overweight/obese subjects to a greater extent than diet alone.