Along with its effects on bone metabolism, vitamin D is an important modulator of the immune
system. Experimental studies have shown that the active metabolite of vitamin D [1,25(OH)2D]
is able to skew the T cell compartment into a more anti-inflammatory state, with inhibition
of Th1 and Th17 cells and promotion of Th2 and T regulatory subsets.
In the context of HIV infection, in which Th1 subpopulations are devoted to inhibit viral
replication, any alteration of the Th1/Th2 balance would be of concern.
The aim of this Randomized Controlled Trial is to test wether oral supplementation with
cholecalciferol could be able: 1) to improve vitamin D status and, 2) to play an
immunomodulatory role, in vertically HIV-infected children and young adults with
hypovitaminosis D.
Phase:
Phase 2
Details
Lead Sponsor:
University of Milan
Treatments:
Cholecalciferol Ergocalciferols Vitamin D Vitamins