Vitamin D Supplementation in RNA-seq Profiles of Single-core Prostate Samples, Among Veterans
Status:
Recruiting
Trial end date:
2022-06-30
Target enrollment:
Participant gender:
Summary
Veterans between the ages of 50-75, who are having a prostate biopsy, will be recruited for
their permission to collect an extra biopsy core for RNA-sequencing. If the participants'
treatment decision is Active Surveillance, they wil be enrolled into the intervention phase
of the study. They will receive supplementation with vitamin D3 (4,000 IU) daily with repeat
(surveillance) prostate biopsy one year later. At that time an extra prostate sample core
will be collected for RNA-sequencing to determine changes over time. Measurements for
allostatic load (body stress) will also be collected at the time of enrollment and at the
repeat prostate biopsy visit.
Phase:
Phase 2
Details
Lead Sponsor:
Medical University of South Carolina
Collaborators:
City of Hope Comprehensive Cancer Center MUSC Psychiatry and Behavioral Sciences Ralph H. Johnson VA Medical Center