Vitamin D Supplementation in Systemic Lupus Erythematosus
Status:
Completed
Trial end date:
2011-01-01
Target enrollment:
Participant gender:
Summary
Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disorder. It mainly involves the
skin, the joints, the nervous system and the kidney and may be life threatening.
SLE is associated with production of autoantibodies and perturbations in regulatory T cells
and T helper lymphocytes producing interleukin (IL)-17 (Th17 cells).
Treatments include corticosteroids, hydroxychloroquine and immunosuppressive agents.
Immunomodulatory effects of vitamin D supplementation in VITRO was recently described,
notably the expansion of Treg able to suppress inflammatory responses mediated by CD4+ and
CD8+ T cells and the decrease of Th17 cells.
Details
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Treatments:
Cholecalciferol Ergocalciferols Vitamin D Vitamins