Vitamin D for Polycystic Ovary Syndrome Clomiphene Resistant Women

• Status: Completed
• Trial end date: 2019-03-30
• Target enrollment: 0
• Participant gender: Female

Summary

This study is determining the therapeutic effect of Vitamin D supplements to Pcos clomiphene resistant polycystic ovarian syndrome Women. Half of patients will receive Vitamin D with metformin while other half metformin only. Then both groups start clomiphene for 3 month

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ain Shams University
• Treatments: Citric Acid; Clomiphene; Enclomiphene; Ergocalciferols; Metformin; Vitamin D; Vitamins; Zuclomiphene

Criteria

Inclusion Criteria:

• Diagnosis of PCOS as defined by the Rotterdam criteria

• Females age 20-35 years old

• BMI 18-30 kg/m2

• 1ry or secondary infertility

• Clomiphene resistant ( patients didn't - show response: ovulate to dose of 200 mg clomid per day for 3 cycles )

• Willingness to comply with study protocol for 5 months

• Willingness to give written informed consent to participate in the study

Exclusion Criteria:

• Previous metformin intake

• ovarian drilling

• tubal factor as evidenced by hysterosalpingogram or laparoscope

• endometrial pathology ex., polyp

• Myometrial pathology ex., adenomyosis or fibroid

• abnormal semen parameters

• Cushing syndrome

• Hyperprolactinemia

• Adrenal secreting tumor